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Low Erythrocyte Manganese & High Arsenic in Unresponsive Hypertensive Female Patient |
| Jul 08 2010 |
Low Erythrocyte Manganese & High Arsenic in Unresponsive Hypertensive Female Patient
Manganese superoxide dismutase (Mn-SOD) plays a pivotal role in endothelial vasodilation via its control of superoxide levels. Moreover, genetic polymorphisms in Mn-SOD have been linked with hypertension. Long-term, low-level arsenic exposure has also been linked with hypertension. High-dose manganese, removal of arsenic exposure and a concurrent detoxification protocol may therefore represent a novel strategy for controlling hypertension in this patient.
SC is a 42 y/o female with unresponsive hypertension. She lives on a rural property in far western Queensland with her husband. The entire population in her area rely on bore water obtained from the Artesian Basin for their drinking water. As such, there are reasonable grounds to suspect SC may be exposed to low levels of arsenic (a common contaminant of bore water in Australia1). Her husband who suffers from unexplained very high ferritin levels has been tested for arsenic and found to have borderline high levels. SR is on a calcium-channel blocker and ACE-inhibitor for management of her blood pressure, albeit with little effect. Below are the results of her red blood cell element analysis.
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